Metalloprotein Inhibitors for the Treatment of Human Diseases

Title:Metalloprotein Inhibitors for the Treatment of Human Diseases

Volume: 16 Issue: 4

Author(s): Yang Yang, Xue-Qin Hu, Qing-Shan Li, Xing-Xing Zhang, Ban-Feng Ruan, Jun Xu and Chenzhong Liao

Affiliation:

Keywords: Chelating, Drug design, Drug development, Magnesium, Metalloprotein, Zinc.

Abstract: Metalloproteins have attracted momentous attentions for the treatment of many human diseases, including cancer, HIV, hypertension, etc. This article reviews the progresses that have been made in the field of drug development of metalloprotein inhibitors, putting emphasis on the targets of carbonic anhydrase, histone deacetylase, angiotensin converting enzyme, and HIV-1 integrase. Many other important metalloproteins are also briefly discussed. The binding and coordination modes of different marketed metalloprotein inhibitors are stated, providing insights to design novel metal binding groups and further novel inhibitors for metalloproteins.

Cite this article as:

Yang Yang, Hu Xue-Qin, Li Qing-Shan, Zhang Xing-Xing, Ruan Ban-Feng, Xu Jun and Liao Chenzhong, Metalloprotein Inhibitors for the Treatment of Human Diseases, Current Topics in Medicinal Chemistry 2016; 16 (4) . https://dx.doi.org/10.2174/1568026615666150813145218