Abstract
A series of styrylquinolines and quinolineamides based on the 8-hydroxyquinoline moiety were investigated as potential antimycobacterial agents. The lipophilicity of the compounds was measured using RP-HPLC and the tests of their activity against Mycobacterium kansasii, the M. avium complex, M. smegmatis, M. abscessus, M. tuberculosis and M. avium paratuberculosis was performed. Several of the compounds that were obtained appeared to be more effective than isoniazid and ciprofloxacin. The 5,7-dinitro-8-hydroxyquinoline derivative possessed the highest potency against M. abscessus and M. Smegmatis, which was about twice as effective as ciprofloxacin, while 2-(2-hydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid appeared to be comparable with the standard drugs that are against the M. avium complex. The structure activity relationships are discussed.
Keywords: Cytotoxicity, drug design, lipophilicity, mycobacterium, quinoline derivatives, styrylquinolines.
Medicinal Chemistry
Title:Investigation of the Antimycobacterial Activity of 8-hydroxyquinolones
Volume: 11 Issue: 8
Author(s): Wioleta Cieslik, Ewelina Spaczynska, Katarzyna Malarz, Dominik Tabak, Eoghan Nevin, Jim O'Mahony, Aidan Coffey, Anna Mrozek-Wilczkiewicz, Josef Jampilek and Robert Musiol
Affiliation:
Keywords: Cytotoxicity, drug design, lipophilicity, mycobacterium, quinoline derivatives, styrylquinolines.
Abstract: A series of styrylquinolines and quinolineamides based on the 8-hydroxyquinoline moiety were investigated as potential antimycobacterial agents. The lipophilicity of the compounds was measured using RP-HPLC and the tests of their activity against Mycobacterium kansasii, the M. avium complex, M. smegmatis, M. abscessus, M. tuberculosis and M. avium paratuberculosis was performed. Several of the compounds that were obtained appeared to be more effective than isoniazid and ciprofloxacin. The 5,7-dinitro-8-hydroxyquinoline derivative possessed the highest potency against M. abscessus and M. Smegmatis, which was about twice as effective as ciprofloxacin, while 2-(2-hydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid appeared to be comparable with the standard drugs that are against the M. avium complex. The structure activity relationships are discussed.
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Cieslik Wioleta, Spaczynska Ewelina, Malarz Katarzyna, Tabak Dominik, Nevin Eoghan, O'Mahony Jim, Coffey Aidan, Mrozek-Wilczkiewicz Anna, Jampilek Josef and Musiol Robert, Investigation of the Antimycobacterial Activity of 8-hydroxyquinolones, Medicinal Chemistry 2015; 11 (8) . https://dx.doi.org/10.2174/1573406410666150807111703
DOI https://dx.doi.org/10.2174/1573406410666150807111703 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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