摘要
非酒精性脂肪肝(NAFLD),代谢综合征的肝表现,是最常见慢性肝病之一,可发展为肝纤维化、肝硬化甚至肝癌。BAFLD的特点是以多因素引起脂肪在肝脏的积聚,这些因素有:脂肪酸摄入量的增加、脂肪从头合成的增加、脂肪酸氧化和极低密度脂蛋白(VLDL)分泌的减少。该疾病的多数治疗方法有减少身体质量指数、通过调整生活方式改善胰岛素抵抗、减肥手术和药物治疗。然而,越来越多的证据显示天然化合物(如多酚类),有利于NAFLD的治疗。这些分子能控制与脂肪新生和脂肪酸氧化有关基因的表达,对肝脏造成降脂效应。其抗氧化、抗炎、抗纤维化和抗脂肪生成的特性使其具有阻止NAFLD发展的潜力。本综述,我们总结了一些化合物,尤其是黄酮类成分的疗效和作用机制,有大量研究报道了这些化合物对NAFLD体内体外模型的评价。
关键词: 抗氧化,黄酮类,胰岛素抵抗,脂质积聚,NAFLD,槲皮素。
Current Medicinal Chemistry
Title:Flavonoids and Related Compounds in Non-Alcoholic Fatty Liver Disease Therapy
Volume: 22 Issue: 25
Author(s): Sandra Pisonero-Vaquero, Javier Gonzalez-Gallego, Sonia Sanchez-Campos and Maria Victoria Garcia-Mediavilla
Affiliation:
关键词: 抗氧化,黄酮类,胰岛素抵抗,脂质积聚,NAFLD,槲皮素。
摘要: Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, is one of the most common chronic liver diseases, which may progress to fibrosis, cirrhosis and hepatocellular carcinoma. NAFLD is characterized by the accumulation of lipids in the liver arising from multiple factors: increased fatty acid uptake, increased de novo lipogenesis, reduced fatty acid oxidation and very low density lipoproteins (VLDL) secretion. Most therapeutic approaches for this disease are often directed at reducing body mass index and improving insulin resistance through lifestyle modifications, bariatric surgery and pharmacological treatments. Nevertheless, there is increasing evidence that the use of natural compounds, as polyphenols, exert multiple benefits on the disorders associated with NAFLD. These molecules seem to be able to regulate the expression of genes mainly involved in de novo lipogenesis and fatty acid oxidation, which contributes to their lipid-lowering effect in the liver. Their antioxidant, anti-inflammatory, antifibrogenic and antilipogenic properties seem to confer on them a great potential as strategy for preventing NAFLD progression. In this review, we summarized the effects of these compounds, especially flavonoids, and their mechanisms of action, that have been reported in several studies carried out in in vitro and in vivo models of NAFLD.
Export Options
About this article
Cite this article as:
Sandra Pisonero-Vaquero, Javier Gonzalez-Gallego, Sonia Sanchez-Campos and Maria Victoria Garcia-Mediavilla , Flavonoids and Related Compounds in Non-Alcoholic Fatty Liver Disease Therapy, Current Medicinal Chemistry 2015; 22 (25) . https://dx.doi.org/10.2174/0929867322666150805094940
DOI https://dx.doi.org/10.2174/0929867322666150805094940 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Proteomic Approach To Porcine Saliva
Current Protein & Peptide Science Behavioral Decision Research Intervention Reduces Risky Sexual Behavior
Current HIV Research Foamy Virus Vectors: An Awaited Alternative to Gammaretro- and Lentiviral Vectors
Current Gene Therapy Involvement of Mesenchymal Stem Cells in Cancer Progression and Metastases
Current Cancer Drug Targets Small Molecule Integrin Antagonists in Cancer Therapy
Mini-Reviews in Medicinal Chemistry A Review on Chitosan in Drug Delivery for Treatment of Neurological and Psychiatric Disorders
Current Pharmaceutical Biotechnology Bioplex Technology: Novel Synthetic Gene Delivery Pharmaceutical Based on Peptides Anchored to Nucleic Acids
Current Pharmaceutical Design Meet Our Editorial Board Member
Mini-Reviews in Medicinal Chemistry Antigen-specific Immunotherapy in Ovarian Cancer and p53 as Tumor Antigen
Current Pharmaceutical Design The Typical Metabolic Modifiers Conferring Improvement in Cancer Resistance
Current Medicinal Chemistry Cancer Preventive Phytochemicals as Speed Breakers in Inflammatory Signaling Involved in Aberrant COX-2 Expression
Current Cancer Drug Targets Oral Inflammation and Bacteremia: Implications for Chronic and Acute Systemic Diseases Involving Major Organs
Cardiovascular & Hematological Disorders-Drug Targets New Strategies for Metabolic Support in Cancer
Current Nutrition & Food Science Treatment Outcome of Three Female Adolescents with Borderline Personality Disorder
Adolescent Psychiatry Engineered Peptides for Applications in Cancer-Targeted Drug Delivery and Tumor Detection
Mini-Reviews in Medicinal Chemistry Stem Cell Based Preclinical Drug Development and Toxicity Prediction
Current Pharmaceutical Design Current Prodrug Design for Drug Discovery
Current Pharmaceutical Design Combining Oncolytic Virotherapy and Cytotoxic Therapies to Fight Cancer
Current Pharmaceutical Design Targeting the Ubiquitin-Proteasome Pathway: An Emerging Concept in Cancer Therapy
Current Topics in Medicinal Chemistry Radioprotection of Normal Tissue to Improve Radiotherapy: The Effect of the Bowman Birk Protease Inhibitor
Current Medicinal Chemistry - Anti-Cancer Agents