Abstract
The peroxisome proliferator-activated receptor –γ (PPARγ) has been identified in a wide range of cancers, including brain, breast, colon, stomach and lung cancers. It belongs to the thyroid/ steroid hormone receptors superfamily. Binding with their special ligands, PPARγ plays important roles in regulating transcription of their target genes. PPARγ activation suppresses the growth of the tumor cells, implicating the anti-tumor potential of PPARγ ligand. Tumors in the nervous system are among the most devastating cancers. This review highlights key advances in understanding the effects of PPARγ ligands in the treatment of tumors in the nervous system.
Keywords: Anti-tumor, chemoprevention, glioblastoma, nervous system, neuroblastoma, peroxisome proliferator-activated receptor γ, thiazolidinediones (TZDs).
Call for Papers in Thematic Issues
Molecular Mechanisms and Translational Strategies Targeting the Disease Immune Microenvironment
This thematic issue aims to highlight recent advances in deciphering the molecular mechanisms underlying the disease immune microenvironment, with a particular focus on cancer and chronic inflammatory conditions. It will bring together cutting-edge research in immune regulation, biomarker discovery, epigenetic remodeling, and post-translational modifications that influence disease progression and therapeutic ...read more
Stem Cells and Their Derivatives in Cardiovascular Diseases and Complications
Cardiovascular diseases (CVDs) are a global health burden. Stem cells and their derivatives, such as extracellular vesicles (EVs), offer therapeutic opportunities for CVDs and their complications. This thematic issue of Current Stem Cell Research & Therapy will showcase the latest research on the mechanisms by which stem cells and EVs ...read more
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