摘要
背景技术人醛脱氢酶2(ALDH2)是醇代谢乙醛解毒中最有效的酶。 ALDH2 * 2突变是由单个核苷酸取代引起的,导致ALDH2酶几乎失活。 ALDH2基因型已经被用作酒精的替代品,以在实现孟德尔随机化方法的相关疾病中获得酒精的因果推论。此外,ALDH2酶对不同疾病有显着影响,表明ALDH2调节剂的潜在治疗价值包括激活剂如Alda-1和抑制剂如黄豆苷苷和黄豆苷原。 目的:本研究旨在系统地讨论ALDH2基因型和ALDH2酶调节因子的影响,突出其流行病学和临床意义。 结论:ALDH2多态性显示为孟德尔随机分析中酒精使用的遗传工具。 ALDH2调节剂具有潜在的治疗价值,因为ALDH2在各种疾病中的重要作用。 ALDH2的遗传多态性和酶活性调节对其流行病学和临床应用具有重要意义。
关键词: 醛脱氢酶2(ALDH2),ALDH2激活剂,ALDH2抑制剂,遗传多态性,孟德尔随机化,观察性流行病学。
Current Drug Targets
Title:ALDH2---The Genetic Polymorphism and Enzymatic Activity Regulation: Their Epidemiologic and Clinical Implications
Volume: 18 Issue: 15
关键词: 醛脱氢酶2(ALDH2),ALDH2激活剂,ALDH2抑制剂,遗传多态性,孟德尔随机化,观察性流行病学。
摘要: Background: The human aldehyde dehydrogenase 2 (ALDH2) is the most effective enzyme in the detoxification of alcohol metabolite acetaldehyde. The ALDH2*2 mutation is caused by a single nucleotide substitution which results in a nearly inactive form of ALDH2 enzyme. The ALDH2 genotype has been used as a surrogate of alcohol to get causal inferences of alcohol in related diseases implementing Mendelian randomization approach. In addition, ALDH2 enzyme has significant effect on different diseases, indicating the potential therapeutic value of ALDH2 regulators including both activators like Alda-1 and inhibitors such as daidzin and daidzein.
Objective: In this review, we aim to systematically discuss the implications of ALDH2 genotype and ALDH2 enzyme regulators, highlighting their epidemiological and clinical importance, respectively.
Conclusion: ALDH2 polymorphism is shown to be a genetic instrument for alcohol use in Mendelian randomization analysis. ALDH2 regulators exhibit potential therapeutic value as the important roles of ALDH2 in various diseases. Both the genetic polymorphism and enzyme activity regulation of ALDH2 are of great importance to their epidemiologic and clinical applications.
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Cite this article as:
ALDH2---The Genetic Polymorphism and Enzymatic Activity Regulation: Their Epidemiologic and Clinical Implications, Current Drug Targets 2017; 18 (15) . https://dx.doi.org/10.2174/1389450116666150727115118
DOI https://dx.doi.org/10.2174/1389450116666150727115118 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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