Hydrazones as a Privileged Structural Linker in Antitubercular Agents: A Review

Title:Hydrazones as a Privileged Structural Linker in Antitubercular Agents: A Review

Volume: 15 Issue: 2

Author(s): Bijo Mathew, Jerad Suresh, Mohamed J. Ahsan, Githa E. Mathew, Dhasthakeer Usman, Puthucode N.S. Subramanyan, Kallivalappil F. Safna and Srinubabu Maddela

Affiliation:

Keywords: Alamar blue assay, nucleophilic addition, tuberculosis.

Abstract: Hydrazones are a versatile linker of connecting various classes of organic compounds with a unique structural feature of hydrogen bonding donor and the hydrogen bonding acceptor region. An extensive number of research has been carried out on hydrazone derivatives as a potent class of antitubercular agents. The present review focuses on the chemistry, antitubercular activity and structure activity relationship (SAR) of diverse classes of phenyl and heterocyclic based hydrazones.

Cite this article as:

Mathew Bijo, Suresh Jerad, Ahsan J. Mohamed, Mathew E. Githa, Usman Dhasthakeer, Subramanyan N.S. Puthucode, Safna F. Kallivalappil and Maddela Srinubabu, Hydrazones as a Privileged Structural Linker in Antitubercular Agents: A Review, Infectious Disorders - Drug Targets 2015; 15 (2) . https://dx.doi.org/10.2174/1871526515666150724104411