Abstract
A series of new N’-(arylidene)-2-[(1-(4-nitrophenyl)-1H-1,2,4-triazol-3-yl)oxy]acetohydrazide derivatives (1- 16) were prepared and tested for theira ntifungal activity against six plant pathogens, three human pathogens and two nonpathogen microorganisms. The target compounds were obtained with a multi-step reaction starting from 4- substitutedarylhydrazine derivatives and the structures of final compounds have been elucidated with IR, NMR, Mass spectroscopy data and elemental analysis results. The antifungal activity of the compounds was determined against eleven different Fusarium, Trichoderma, Aspergillus and Penicilliumspeciesby using microdilution method. Most of the target compounds showed excellent antifungal activity against a variety of fungal pathogens.
Keywords: Salicylidene hydrazide, 1, 2, 4-triazole, antifungal activity.
Letters in Drug Design & Discovery
Title:Synthesis and Antifungal Activity Evaluation of New 1,2,4-Triazole Derivatives Bearing Salicylidene Hydrazide Moiety
Volume: 13 Issue: 2
Author(s): Seref Demirayak, Ismail Kayagil, Leyla Yurttas and Sevda Er
Affiliation:
Keywords: Salicylidene hydrazide, 1, 2, 4-triazole, antifungal activity.
Abstract: A series of new N’-(arylidene)-2-[(1-(4-nitrophenyl)-1H-1,2,4-triazol-3-yl)oxy]acetohydrazide derivatives (1- 16) were prepared and tested for theira ntifungal activity against six plant pathogens, three human pathogens and two nonpathogen microorganisms. The target compounds were obtained with a multi-step reaction starting from 4- substitutedarylhydrazine derivatives and the structures of final compounds have been elucidated with IR, NMR, Mass spectroscopy data and elemental analysis results. The antifungal activity of the compounds was determined against eleven different Fusarium, Trichoderma, Aspergillus and Penicilliumspeciesby using microdilution method. Most of the target compounds showed excellent antifungal activity against a variety of fungal pathogens.
Export Options
About this article
Cite this article as:
Demirayak Seref, Kayagil Ismail, Yurttas Leyla and Er Sevda, Synthesis and Antifungal Activity Evaluation of New 1,2,4-Triazole Derivatives Bearing Salicylidene Hydrazide Moiety, Letters in Drug Design & Discovery 2016; 13 (2) . https://dx.doi.org/10.2174/1570180812666150723001545
DOI https://dx.doi.org/10.2174/1570180812666150723001545 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Platelet Ca2+ATPases: Identification and Regulation in Hypertension
Current Hypertension Reviews Cutting the Limits of Aminobisphosphonates: New Strategies for the Potentiation of their Anti-Tumour Effects
Current Cancer Drug Targets Mechanisms of Action of DNA-Damaging Anticancer Drugs in Treatment of Carcinomas: Is Acute Apoptosis an “Off-Target” Effect?
Mini-Reviews in Medicinal Chemistry Current Perspectives on the Role of Nrf2 in 5-Fluorouracil Resistance in Colorectal Cancer
Anti-Cancer Agents in Medicinal Chemistry The Therapeutic Potential of RNA Interference: Novel Approaches for Cancer Treatment
Current Pharmaceutical Biotechnology Novel Therapies Against Aggressive and Recurrent Epithelial Cancers by Molecular Targeting Tumor- and Metastasis-Initiating Cells and Their Progenies
Anti-Cancer Agents in Medicinal Chemistry SYNTHESIS AND APPLICATIONS OF Fe3O4/SiO2 CORE-SHELL MATERIALS
Current Pharmaceutical Design Structural Basis and Therapeutic Implication of the Interaction of CCN Proteins with Glycoconjugates
Current Pharmaceutical Design Personalized Medicine, Bioethics and Social Responsibilities: Re-thinking the Pharmaceutical Industry to Remedy Inequities in Patient Care and International Health
Current Pharmacogenomics and Personalized Medicine CD147/EMMPRIN and CD44 are Potential Therapeutic Targets for Metastatic Prostate Cancer
Current Cancer Drug Targets Molecular Modeling Applied to Anti-Cancer Drug Development
Anti-Cancer Agents in Medicinal Chemistry Molecular Targeting of Drug Delivery Systems to Cancer
Current Drug Targets Noninvasive Assessment of Cytokines in Occupational Respiratory Diseases
Recent Patents on Inflammation & Allergy Drug Discovery The Novel Functions of cGMP-Specific Phosphodiesterase 5 and its Inhibitors in Carcinoma Cells and Pulmonary/Cardiovascular Vessels
Current Topics in Medicinal Chemistry Acute Lymphoblastic Leukemia and Regulatory T cells: Biomarkers and Immunopathogenesis
Current Immunology Reviews (Discontinued) The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious Diseases
Anti-Infective Agents in Medicinal Chemistry Upstream Processing of Plasmid DNA for Vaccine and Gene Therapy Applications
Recent Patents on Biotechnology Amberlyst-15® in PEG-400: Green Synthesis of 3-Benzoyl-5-Hydroxy Benzofuran and Naphtho[1,2-b]furan Derivatives at Room Temperature
Letters in Organic Chemistry Vascular Endothelial Growth Factor (VEGF) in the Pathogenesis of Diabetic Nephropathy of Type 1 Diabetes Mellitus
Current Drug Targets Diagnosis and Management of Heart Failure with Preserved Ejection Fraction: 10 Key Lessons
Current Cardiology Reviews