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Current Microwave Chemistry

Editor-in-Chief

ISSN (Print): 2213-3356
ISSN (Online): 2213-3364

Rapid and Convenient CuCl2 Catalysed Microwave-Assisted Synthesis of Novel Spiro [indoline-3,4'-quinoline] Derivatives

Author(s): Mayuri A. Borad, Manoj N. Bhoi, Darshita M. Patel and Hitesh D. Patel

Volume 3, Issue 2, 2016

Page: [166 - 172] Pages: 7

DOI: 10.2174/2213335602666150722232613

Price: $65

Abstract

A rapid and efficient, one-pot, three-component, microwave-assisted synthesis of spiro[indoline-3,4'-quinoline] derivatives has been accomplished through three-component Knoevenagel/ Michael addition reaction of isatin, malononitrile and various amine derivative in very good to outstanding yields under CuCl2 catalyst. The main benefits of this protocol are simple work-up, trivial and eco-friendly reaction conditions. Biological characterization, including antibacterial was also evaluated.

Keywords: CuCl2, isatin, microwave-assisted synthesis, multi-component reactions, spiro compound.


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