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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry

Author(s): Samir Acherar, Ludovic Colombeau, Celine Frochot and Regis Vanderesse

Volume 22, Issue 28, 2015

Page: [3217 - 3254] Pages: 38

DOI: 10.2174/0929867322666150716115832

Price: $65


The aim of this review is to provide a summary of the use of copper-catalyzed azide-alkyne cycloaddition (CuAAC) in the synthesis of porphyrin, chlorin and phthalocyanine derivatives for different types of therapeutic applications. The click reaction is a powerful and versatile tool for scientists working on the synthesis of various symmetrically and asymmetrically substituted tetrapyrrolic derivatives. For example, click chemistry is widely used for the elaboration of photosensitizer conjugates for photodynamic therapy applications. Other biological applications are also described.

Keywords: Click chemistry, Huisgen's cycloaddition, photodynamic therapy, photosensitizers, therapeutic.

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