Abstract
One of the major advances in the recent history of the treatment of HIV infections has been the development of different classes of effective antiretroviral drugs. In particular, the reverse transcriptase (RT) inhibitors still represent the majority of the clinically used anti-HIV drugs and constitute the main backbone of currently employed combinatorial regimens. Highly active antiretroviral combination chemotherapy (HAART), combining RT and protease inhibitors, has proven the most effective approach to treat HIV disease, since it has been shown to markedly suppress viral replication and appearance of drug resistance for a relatively long period. These therapies, however, do not constitute a definitive cure, since they are not able to completely eradicate the virus from the infected individual. Beside drug toxicity problems, the emergence of drug resistance associated with the particular regimen employed further complicates the situation. This review will summarise the most recent achievements, as well as the future directions in the development of novel anti-RT compounds.
Keywords: nrtis, nnrtis, hiv-1 reverse trasncriptase, haart, drug resistance, toxicity
Current Drug Metabolism
Title: HIV-1 Reverse Transcriptase Inhibitors: Current Issues and Future Perspectives
Volume: 5 Issue: 4
Author(s): G. A. Locatelli, R. Cancio, S. Spadari and G. Maga
Affiliation:
Keywords: nrtis, nnrtis, hiv-1 reverse trasncriptase, haart, drug resistance, toxicity
Abstract: One of the major advances in the recent history of the treatment of HIV infections has been the development of different classes of effective antiretroviral drugs. In particular, the reverse transcriptase (RT) inhibitors still represent the majority of the clinically used anti-HIV drugs and constitute the main backbone of currently employed combinatorial regimens. Highly active antiretroviral combination chemotherapy (HAART), combining RT and protease inhibitors, has proven the most effective approach to treat HIV disease, since it has been shown to markedly suppress viral replication and appearance of drug resistance for a relatively long period. These therapies, however, do not constitute a definitive cure, since they are not able to completely eradicate the virus from the infected individual. Beside drug toxicity problems, the emergence of drug resistance associated with the particular regimen employed further complicates the situation. This review will summarise the most recent achievements, as well as the future directions in the development of novel anti-RT compounds.
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Cite this article as:
Locatelli A. G., Cancio R., Spadari S. and Maga G., HIV-1 Reverse Transcriptase Inhibitors: Current Issues and Future Perspectives, Current Drug Metabolism 2004; 5 (4) . https://dx.doi.org/10.2174/1389200043335504
DOI https://dx.doi.org/10.2174/1389200043335504 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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