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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Synthetic Aziridines in Medicinal Chemistry: A Mini-Review

Author(s): Girija S. Singh

Volume 16, Issue 11, 2016

Page: [892 - 904] Pages: 13

DOI: 10.2174/1389557515666150709122244

Price: $65


Azaheterocyclic compounds are well-known to have diverse types of biological activity. Among them, azacyclopropanes, commonly referred as aziridines, occupy a prominent place in synthetic organic and medicinal chemistry due to its occurrence in natural resources, complexity involved in synthesis due to ring-strain, building blocks in organic synthesis, and its biological properties. Several novel compounds containing aziridine ring have been designed and synthesized recently by medicinal chemists for evaluating their biological profile. A number of compounds are reported as cysteine protease inhibitors, antibacterial, antifungal, anticancer, antileishmanial, and antimalarial agents. This review article summarizes the biological activity of such compounds. The preparation of such compounds is also described.

Keywords: Antimalarial, antimicrobial, anticancer, Aziridines, cysteine protease inhibitors.

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