Abstract
Glioblastoma is the most common adult malignant primary brain tumor, and carries a dismal prognosis. After initial standard radiation therapy and chemotherapy with temozolomide, few standard chemotherapy options are available. In the last two decades, a growing understanding of molecular pathogenesis of glioblastoma has turned our focus toward targeted therapy. This review will discuss our current understanding of gliomagenesis and highlight the clinical attempts to manipulate these vital pathways, describing past and current studies, and future directions.
Keywords: Cell signaling, glioblastoma, gliomagenesis, monoclonal antibodies, targeted therapy, tyrosine kinase inhibitors.
Current Cancer Therapy Reviews
Title:Targeted Therapy for Glioblastoma: Lessons Learned and Future Directions
Volume: 11 Issue: 1
Author(s): Nicole A Shonka, Suprit Gupta and Pankaj K. Singh
Affiliation:
Keywords: Cell signaling, glioblastoma, gliomagenesis, monoclonal antibodies, targeted therapy, tyrosine kinase inhibitors.
Abstract: Glioblastoma is the most common adult malignant primary brain tumor, and carries a dismal prognosis. After initial standard radiation therapy and chemotherapy with temozolomide, few standard chemotherapy options are available. In the last two decades, a growing understanding of molecular pathogenesis of glioblastoma has turned our focus toward targeted therapy. This review will discuss our current understanding of gliomagenesis and highlight the clinical attempts to manipulate these vital pathways, describing past and current studies, and future directions.
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Shonka A Nicole, Gupta Suprit and Singh K. Pankaj, Targeted Therapy for Glioblastoma: Lessons Learned and Future Directions, Current Cancer Therapy Reviews 2015; 11 (1) . https://dx.doi.org/10.2174/157339471101150706122425
DOI https://dx.doi.org/10.2174/157339471101150706122425 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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