摘要
FoxQ1是多种肿瘤的致癌基因,并编码叉头框转录因子FoxQ1。然而,关于FoxQ1在胰腺癌(PC)中的作用知之甚少。在这项研究中,我们通过定量PCR和组织芯片的免疫组织化学染色(IHC)来研究PC细胞系和人胰腺癌组织中FoxQ1的表达,研究胰腺癌患者组织中FoxQ1的水平和临床病理特征的临床相关性。我们发现,在PC细胞系和肿瘤组织中FoxQ1的mRNA表达上调。免疫组化结果显示,FoxQ1主要表达于胰腺癌细胞的胞浆中,较小程度上表达与细胞核。胰腺癌组织中FoxQ1蛋白水平显著高于相应的非癌变组织,与肿瘤的分化程度呈正相关。单因素和多因素生存分析显示, FoxQ1高表达与TNM分期晚期的患者有较差的预后(HR = 185.6,95% CI 1.065 - 3.234,P = 0.029;HR = 209.1,95% CI 1.181-3.705,P = 0.01)。这些数据表明,FoxQ1表达与PC患者的总体生存期呈负相关,因此这种蛋白可能代表了胰腺癌的一种新的分子靶点和新的预后标志物。
关键词: 胰腺癌,FoxQ1,预后,存活,上皮间质转化,分子靶标。
Current Molecular Medicine
Title:FoxQ1 is a Novel Molecular Target for Pancreatic Cancer and is Associated with Poor Prognosis
Volume: 15 Issue: 5
Author(s): H. -X. Zhan, J. -W. Xu, L. Wang, D. Wu, G. -Y. Zhang and S. -Y. Hu
Affiliation:
关键词: 胰腺癌,FoxQ1,预后,存活,上皮间质转化,分子靶标。
摘要: FOXQ1 is an oncogene for a variety of tumors and encodes the forkhead boxrelated transcription factor FoxQ1. However, little is known about the role of FoxQ1 in pancreatic cancer (PC). In this study, we examined FoxQ1 expression in PC cell lines and human PC tissues by quantitative PCR and tissue microarray based immunohistochemical staining (IHC), and investigated the clinical correlation between FoxQ1 tissue levels and the clinicopathological characteristics of PC patients. We found that FoxQ1 mRNA expression was up-regulated both in PC cell lines and tumor tissues. IHC results revealed that FoxQ1 was mainly expressed in the cytoplasm, and to a lesser extent in the nucleus of PC cells. FoxQ1 protein levels were significantly higher in PC tissues when compared with matched non-cancerous tissues, and associated positively with the degree of tumor differentiation. Univariate and multivariate survival analysis revealed that patients with high FoxQ1 expression and advanced TNM stage had poor prognosis (HR=1.856, 95%CI 1.065- 3.234, P=0.029; HR=2.091, 95%CI 1.181-3.705, P=0.01). These data indicate that FoxQ1 expression is negatively associated with the overall survival of PC patients, and that this protein may therefore represent a novel molecular target and new prognostic biomarker for PC.
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Cite this article as:
H. -X. Zhan, J. -W. Xu, L. Wang, D. Wu, G. -Y. Zhang and S. -Y. Hu , FoxQ1 is a Novel Molecular Target for Pancreatic Cancer and is Associated with Poor Prognosis, Current Molecular Medicine 2015; 15 (5) . https://dx.doi.org/10.2174/1566524015666150630125247
DOI https://dx.doi.org/10.2174/1566524015666150630125247 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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