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Current Green Chemistry


ISSN (Print): 2213-3461
ISSN (Online): 2213-347X

A Survey of the Palladium-Catalyzed Hirao Reaction with Emphasis on Green Chemical Aspects

Author(s): Erzsébet Jablonkai and György Keglevich

Volume 2, Issue 4, 2015

Page: [379 - 391] Pages: 13

DOI: 10.2174/2213346102999150630114117


The Pd-catalyzed P–C couplings of aryl, hetaryl and vinyl derivatives and species with a P(O)H function, typically dialkyl phosphites and secondary phosphine oxides giving rise to phosphonates and phosphine oxides are summarized with special emphasis on the green chemical variations. A great variety of reactions are discussed to demonstrate the different conditions and catalyst systems described. environmentally friendly protocols include the use of a phase transfer catalyst and the microwave technique. The best way is to perform the P–C coupling reactions under Pligand- free and solvent-free conditions.

Keywords: Hirao reaction, P-C coupling, Pd-catalyst, phosphonates, phosphinates, phosphine oxides, P-ligand-free.

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