Generic placeholder image

Current Genomics


ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Transcriptional Complexity from Dynamic Interaction Networks In Vivo

Author(s): Miroslav Dundr and Tom Misteli

Volume 5, Issue 7, 2004

Page: [559 - 566] Pages: 8

DOI: 10.2174/1389202043348823

Price: $65


The last decades have lead to the identification and characterization of most key steps in gene expression including chromatin remodeling, transcription, RNA processing, export and translation. Extensive biochemical, genetic and molecular approaches have not only revealed the key players involved in these processes, but have yielded detailed insights into the molecular behavior of many. Despite the wealth of molecular and structural information of distinct processes of gene expression and of single molecular components, fundamental aspects of the system behavior of the gene expression machinery have remained elusive. It is just now becoming clear that the single steps in the gene expression process are tightly interlinked and virtually nothing is known about how the various components of genome regulation and expression machineries are integrated into presumably complex networks of interactions and pathways. Even more elusive has been the elucidation of how gene expression processes occur in their natural setting of the cell nucleus in intact living cells. Recent advances in qualitative and quantitative imaging methods are beginning to provide tools to study the complexity of the gene expression process in living cells. We briefly review here some emerging in vivo imaging technologies and summarize the recent results and the conceptual impact these methods are making on understanding transcriptional complexity in vivo.

Keywords: chromatin, transcription, dynamics, diffusion, gene expression, networks, stochastic

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy