Generic placeholder image

Current Microwave Chemistry


ISSN (Print): 2213-3356
ISSN (Online): 2213-3364

First Bioreduction of 2,2,2-trifluoro-1-phenylethanone by Whole Hyphae of Marine Fungus Mucor racemosus CBMAI 847 Under Microwave Radiation

Author(s): Sandra Santos Ribeiroa, Lara Durães Sette and André Luiz Meleiro Porto Meleiro Porto

Volume 3, Issue 2, 2016

Page: [92 - 96] Pages: 5

DOI: 10.2174/2213335602666150616222320

Price: $65


This paper reports on the asymmetric reduction of 2,2,2-trifluoro-1-phenylethanone 1a to the corresponding (S)-2,2,2-trifluoro-1-phenylethanol 1b by marine fungus M. racemosus CBMAI 847 under conventional heating (CH) and microwave radiation (MW). The results show that (S)-alcohol was obtained with good conversion (64-100%) and enantiomeric excess (74-99%) for both methods performed under conventional heating (orbital shaking) and microwave radiation. When 2,2,2- trifluoro-1-phenylethanone 1a was reduced by fungus under microwave radiation, the methodology showed to be very efficient to obtain enantiomerically pure alcohol 1b in comparison to the conventional heating. This is the first report on the use of microwave-assistant in biocatalytic reactions catalyzed by marine fungus.

Keywords: Biocatalysis, bioreduction, fluoroketone, microwave radiation, Mucor racemosus, whole cells.Biocatalysis, bioreduction, fluoroketone, microwave radiation, Mucor racemosus, whole cells.

« Previous

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy