Generic placeholder image

Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Neural Basis of Anhedonia and Amotivation in Patients with Schizophrenia: The Role of Reward System

Author(s): Jung Suk Lee, Suwon Jung, Il Ho Park and Jae-Jin Kim

Volume 13, Issue 6, 2015

Page: [750 - 759] Pages: 10

DOI: 10.2174/1570159X13666150612230333

Price: $65


Anhedonia, the inability to feel pleasure, and amotivation, the lack of motivation, are two prominent negative symptoms of schizophrenia, which contribute to the poor social and occupational behaviors in the patients. Recently growing evidence shows that anhedonia and amotivation are tied together, but have distinct neural correlates. It is important to note that both of these symptoms may derive from deficient functioningof the reward network. A further analysis into the neuroimaging findings of schizophrenia shows that the neural correlates overlap in the reward network including the ventral striatum, anterior cingulate cortex and orbitofrontal cortex. Other neuroimaging studies have demonstrated the involvement of the default mode network in anhedonia. The identification of aspecific deficit in hedonic and motivational capacity may help to elucidatethe mechanisms behind social functioning deficits in schizophrenia, and may also lead to more targetedtreatment of negative symptoms.

Keywords: Amotivation, anhedonia, anterior cingulate cortex, orbitofrontal cortex, reward system, schizophrenia, ventral striatum.

Graphical Abstract

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy