Abstract
An efficient, mild, cost effective and eco-friendly synthesis of 2,3- dihydroquinazoline- 4(1H)-ones is described in which isatoic anhydride, primary amines and variety of aldehydes react in the presence of citric acid as a green, bioorganic and inexpensive catalyst via rapid one-pot threecomponent reaction in boiling ethanol.
Keywords: Aldehydes, bioorganic catalyst, citric acid, 2, 3-dihydroquinazoline-4(1H)-ones, isatoic anhydride, multicomponent synthesis, primary amines.
Current Organocatalysis
Title:Citric Acid: A Green Bioorganic Catalyst for One-Pot Three-Component Synthesis of 2,3-dihydroquinazoline-4 (1H)-ones
Volume: 3 Issue: 1
Author(s): Nafiseh Fahimi and Ali Reza Sardarian
Affiliation:
Keywords: Aldehydes, bioorganic catalyst, citric acid, 2, 3-dihydroquinazoline-4(1H)-ones, isatoic anhydride, multicomponent synthesis, primary amines.
Abstract: An efficient, mild, cost effective and eco-friendly synthesis of 2,3- dihydroquinazoline- 4(1H)-ones is described in which isatoic anhydride, primary amines and variety of aldehydes react in the presence of citric acid as a green, bioorganic and inexpensive catalyst via rapid one-pot threecomponent reaction in boiling ethanol.
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Cite this article as:
Fahimi Nafiseh and Reza Sardarian Ali, Citric Acid: A Green Bioorganic Catalyst for One-Pot Three-Component Synthesis of 2,3-dihydroquinazoline-4 (1H)-ones, Current Organocatalysis 2016; 3 (1) . https://dx.doi.org/10.2174/2213337202666150602221505
DOI https://dx.doi.org/10.2174/2213337202666150602221505 |
Print ISSN 2213-3372 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3380 |
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