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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Crystallization Methods for Preparation of Nanocrystals for Drug Delivery System

Author(s): Yuan Gao, Jingkang Wang, Yongli Wang, Qiuxiang Yin, Brian Glennon, Jian Zhong, Jinbo Ouyang, Xin Huang and Hongxun Hao

Volume 21, Issue 22, 2015

Page: [3131 - 3139] Pages: 9

DOI: 10.2174/1381612821666150531164350

Price: $65


Low water solubility of drug products causes delivery problems such as low bioavailability. The reduced particle size and increased surface area of nanocrystals lead to the increasing of the dissolution rate. The formulation of drug nanocrystals is a robust approach and has been widely applied to drug delivery system (DDS) due to the significant development of nanoscience and nanotechnology. It can be used to improve drug efficacy, provide targeted delivery and minimize side-effects. Crystallization is the main and efficient unit operation to produce nanocrystals. Both traditional crystallization methods such as reactive crystallization, anti-solvent crystallization and new crystallization methods such as supercritical fluid crystallization, high-gravity controlled precipitation can be used to produce nanocrystals. The current mini-review outlines the main crystallization methods addressed in literature. The advantages and disadvantages of each method were summarized and compared.

Keywords: Crystallization methods, drug delivery system, formulation, hydrophobic drugs, nanocrystals, nanonization.

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