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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Environmentally Benign Synthetic Protocol for the Synthesis of Spiroquinazolinones Using Sustainable and Recyclable Choline Chloride Based Deep Eutectic Mixture

Author(s): Yogesh Kumar Tailor, Sarita Khandelwal, Hemant Kumar Jain and Mahendra Kumar

Volume 12, Issue 4, 2015

Page: [484 - 491] Pages: 8

DOI: 10.2174/157017941204150522190425

Price: $65


Diversity oriented, efficient and environmentally benign synthetic protocol has been presented for the synthesis of spiroquinazolinones. The hybrid drug-like small molecules incorporating medicinally privileged heterocyclic systems have been synthesized by tandem reaction of 3-aminocrotonnitrile, phenyl hydrazine/ hydrazine hydrate, isatoic anhydride and isatin using deep eutectic solvent as efficient catalyst and environmentally benign reaction medium.

Keywords: Deep eutectic solvent, HBD (Hydrogen bond donor), Ionic liquid, Tandem reaction, Privileged heterocyclic structure, Spiroquinazolinone.

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