An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling

Title:An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling

Volume: 22 Issue: 7

Author(s): Jelena Krstic, Hristina Obradovic, Tamara Kukolj, Slavko Mojsilovic, Ivana Okic-Dordevic, Diana Bugarski and Juan F. Santibanez

Affiliation:

Keywords: Expression, Interleukin-17, interleukin-17 receptor A, receptor interaction, regulation, signaling pathways.

Abstract: Interleukin-17A (IL-17A) and its receptor (IL-17RA) are prototype members of IL-17 ligand/receptor family firstly identified in CD⁴⁺ T cells, which comprises six ligands (IL-17A to IL- 17F) and five receptors (IL-17RA to IL-17RE). IL-17A is predominantly secreted by T helper 17 (Th17) cells, and plays important roles in the development of autoimmune and inflammatory diseases. IL-17RA is widely expressed, and forms a complex with IL-17RC. Binding of IL-17A to this receptor complex triggers the activation of several intracellular signaling pathways. In this review, we aimed to summarize literature data about molecular features of IL-17A and IL-17RA from gene to mature protein. We are also providing insight into regulatory mechanisms, protein structural conformation, including ligand-receptor interaction, and an overview of signaling pathways. Our aim was to compile the data on molecular characteristics of IL-17A and IL-17RA which may help in the understanding of their functions in health and disease.

Cite this article as:

Krstic Jelena, Obradovic Hristina, Kukolj Tamara, Mojsilovic Slavko, Okic-Dordevic Ivana, Bugarski Diana and Santibanez F. Juan, An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling, Protein & Peptide Letters 2015; 22 (7) . https://dx.doi.org/10.2174/0929866522666150520145554