Abstract
1,3-dipolar cycloadditions have been studied extensively for decades. The advantages of this synthetic approach may be increased further by applying microwave irradiation. The substrates for 1,3CA reactions are particularly sensitive to microwave heating due to their dipolar nature. Furthermore, the lack of solvent effects and a catalyst that may be applied in the solid phase make these reactions even more suitable for microwave enhancement. In this review we present the advantages of microwave heating in the synthesis of nitrogen heterocycles through 1,3-dipolar cycloaddition. Although it has been studied for years, this area of synthetic chemistry still requires further elucidation.
Keywords: Azoles, azomethines, click chemistry, cycloaddition, microwave synthesis, nitrile imines.
Current Organic Chemistry
Title:Microwave-Assisted 1,3-dipolar Cycloadditions to Nitrogen Containing Heterocycles
Volume: 19 Issue: 14
Author(s): Wioleta Cieslik, Maciej Serda and Robert Musiol
Affiliation:
Keywords: Azoles, azomethines, click chemistry, cycloaddition, microwave synthesis, nitrile imines.
Abstract: 1,3-dipolar cycloadditions have been studied extensively for decades. The advantages of this synthetic approach may be increased further by applying microwave irradiation. The substrates for 1,3CA reactions are particularly sensitive to microwave heating due to their dipolar nature. Furthermore, the lack of solvent effects and a catalyst that may be applied in the solid phase make these reactions even more suitable for microwave enhancement. In this review we present the advantages of microwave heating in the synthesis of nitrogen heterocycles through 1,3-dipolar cycloaddition. Although it has been studied for years, this area of synthetic chemistry still requires further elucidation.
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Cite this article as:
Cieslik Wioleta, Serda Maciej and Musiol Robert, Microwave-Assisted 1,3-dipolar Cycloadditions to Nitrogen Containing Heterocycles, Current Organic Chemistry 2015; 19 (14) . https://dx.doi.org/10.2174/1385272819666150518103414
DOI https://dx.doi.org/10.2174/1385272819666150518103414 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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