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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Microwave-Assisted 1,3-dipolar Cycloadditions to Nitrogen Containing Heterocycles

Author(s): Wioleta Cieslik, Maciej Serda and Robert Musiol

Volume 19, Issue 14, 2015

Page: [1410 - 1427] Pages: 18

DOI: 10.2174/1385272819666150518103414

Price: $65


1,3-dipolar cycloadditions have been studied extensively for decades. The advantages of this synthetic approach may be increased further by applying microwave irradiation. The substrates for 1,3CA reactions are particularly sensitive to microwave heating due to their dipolar nature. Furthermore, the lack of solvent effects and a catalyst that may be applied in the solid phase make these reactions even more suitable for microwave enhancement. In this review we present the advantages of microwave heating in the synthesis of nitrogen heterocycles through 1,3-dipolar cycloaddition. Although it has been studied for years, this area of synthetic chemistry still requires further elucidation.

Keywords: Azoles, azomethines, click chemistry, cycloaddition, microwave synthesis, nitrile imines.

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