Perspectives On Membrane-associated Progesterone Receptors As Prospective Therapeutic Targets

Title:Perspectives On Membrane-associated Progesterone Receptors As Prospective Therapeutic Targets

Volume: 17 Issue: 10

Author(s): Sae Hasegawa, Mayu Kasubuchi, Kazuya Terasawa and Ikuo Kimura

Affiliation:

Keywords: Progesterone, PGRMC1, PGRMC2, neudesin, neuferricin, cancer.

Abstract: Progesterone receptor membrane components 1 and 2, neudesin, and neuferricin belong to the membraneassociated progesterone receptor (MAPR) family. Recently, sex steroid membrane receptors have gained attention because of their potential involvement in sex hormone-mediated rapid non-genomic effects, which cannot currently be explained by the genomic action of nuclear receptors. Progesterone may increase cell proliferation and survival via nongenomic effects including the activation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3- kinase (PI3K) pathways through MAPRs. Moreover, the unique expression of MAPRs suggests that they could be used as biomarkers and drug targets for sex steroid-related cancers and other diseases. In this review, we summarize the physiological roles of the MAPRs, provide a comprehensive overview of their progesterone-mediated non-genomic actions, and discuss new insights into their potential as therapeutic targets.

Cite this article as:

Hasegawa Sae, Kasubuchi Mayu, Terasawa Kazuya and Kimura Ikuo, Perspectives On Membrane-associated Progesterone Receptors As Prospective Therapeutic Targets, Current Drug Targets 2016; 17 (10) . https://dx.doi.org/10.2174/1389450116666150518102651