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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

An update on Anti-inflammatory Compounds: A Review

Author(s): Ashwani Kumar Dhingra, Bhawna Chopra, Rameshwar Dass and Sanjeev Kumar Mittal

Volume 14 , Issue 2 , 2015

Page: [81 - 97] Pages: 17

DOI: 10.2174/1871523014666150514102027

Price: $65

Abstract

Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process. Also, it has been reported to be associated with the onset of various cancers. An effective anti-inflammatory drug should be able to inhibit the development of inflammation without interfering in normal homeostasis. Current approaches to overcome the inflammation include the use of immune selective anti-inflammatory derivatives, selective glucocorticoid receptor agonist, resolvins and protectins and TNF inhibitors. A number of herbal drugs have been identified in the past that can target inflammatory cytokines. This review mainly focuses on the newer molecules to combat the inflammation and also emphasise on various studies carried out in the past. Thus, the high prevalence of inflammation obliges the development of new drugs; therefore, a safe and efficient drug molecule to confer protection against inflammation is urgently needed.

Keywords: Inflammation, NSAIDs, ImSAIDS, glucocorticoids, SEGRA, resolvins.

Graphical Abstract

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