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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Current Research and Development of Carbon–Hydrogen (C–H) Activations in Catalyzing Organic Syntheses

Author(s): Jin-Gang Yu, Zhi-Hang Wang, Qi Liu, Xiao-Qing Chen, Xin-Yu Jiang and Fei-Peng Jiao

Volume 12, Issue 4, 2015

Page: [385 - 390] Pages: 6

DOI: 10.2174/1570179412999150508173735

Price: $65


To generate series of useful compounds from hydrocarbons, various reactions which are able to satisfy these requests such as addition reactions to carbon/carbon multiple bonds, nucleophilic ring-opening reactions, carbonyl chemistry of the “non-aldol” type, cycloaddition reactions and so on have been studied in-depth. And in general, the preactivation of coupling synthons is always required for such cross-coupling methodologies. However, some existing downsides such as complicated processes and low efficiencies have kept the costs of the classical cross-coupling reactions very high. Due to its advantages such as higher yields of the desired product, relatively fewer byproducts and higher functional-group tolerance over the classical cross-coupling reactions, direct C-H functionalization is thought to be one of the most atom-economical synthetic processes. To develop better, faster, cheaper ways for converting the highly abundant hydrocarbons to value-added chemicals, carbon–hydrogen (C–H) activation is becoming one of the most powerful synthetic tools. As time goes on, C-H activation will find its wider application in a variety of catalytic processes in the pharmaceutical industry, materials science and other industries.

Keywords: Catalytic synthesis, C-H activation, High efficiency, Metal complexes, Transition metals.

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