Abstract
To generate series of useful compounds from hydrocarbons, various reactions which are able to satisfy these requests such as addition reactions to carbon/carbon multiple bonds, nucleophilic ring-opening reactions, carbonyl chemistry of the “non-aldol” type, cycloaddition reactions and so on have been studied in-depth. And in general, the preactivation of coupling synthons is always required for such cross-coupling methodologies. However, some existing downsides such as complicated processes and low efficiencies have kept the costs of the classical cross-coupling reactions very high. Due to its advantages such as higher yields of the desired product, relatively fewer byproducts and higher functional-group tolerance over the classical cross-coupling reactions, direct C-H functionalization is thought to be one of the most atom-economical synthetic processes. To develop better, faster, cheaper ways for converting the highly abundant hydrocarbons to value-added chemicals, carbon–hydrogen (C–H) activation is becoming one of the most powerful synthetic tools. As time goes on, C-H activation will find its wider application in a variety of catalytic processes in the pharmaceutical industry, materials science and other industries.
Keywords: Catalytic synthesis, C-H activation, High efficiency, Metal complexes, Transition metals.
Graphical Abstract
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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