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Current Molecular Pharmacology

Editor-in-Chief

ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

Emerging Alternative Functions for the Auxiliary Subunits of the Voltage- Gated Calcium Channels

Author(s): Franz Hofmann, Anouar Belkacemi and Veit Flockerzi

Volume 8 , Issue 2 , 2015

Page: [162 - 168] Pages: 7

DOI: 10.2174/1874467208666150507110202

Price: $65

Abstract

Voltage gated calcium channels (Cav) are composed of up to five proteins: The ion conducting pore subunit α1 and the auxiliary subunits α2, δ, β, and γ. Recent reports show that Cavα1 and Cavβ comprise the calcium channel core complex and that β, α2 δ and γ may serve additional roles that are independent of the Cavα1 subunit. This short review will summarize these emerging functions.

Keywords: Auxiliary subunits, heart, insulin secretion, neurons, non-smooth muscle cells, pain perception voltage-gated calcium channel.

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