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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

A Simple and Efficient Procedure for Knoevenagel Reaction Promoted by Imidazolium-Based Ionic Liquids

Author(s): Xiaomei Hu, Conelius Ngwa and Qinguo Zheng

Volume 13 , Issue 1 , 2016

Page: [101 - 110] Pages: 10

DOI: 10.2174/1570179412666150505185134

Price: $65

Abstract

Various room temperature ionic liquids (RTILs), notably, 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO]¯ , have been used to promote the Knoevenagel condensation to afford substituted olefins. All reactions proceeded effectively in the absence of any other catalysts or co-solvents with good to excellent yields. This method is simple and applicable to reactions involving a wide range of aldehydes and ketones with methylene compounds. The ionic liquid can be recycled without noticeable reduction of its catalytic activity. A plausible reaction mechanism is proposed.

Keywords: Carbonyl compounds, catalysis, ionic liquids, Knoevenagel condensation, olefins.

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