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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Orthogonally Protected Oxadiazole-Based Building Blocks: Synthesis and Characterization

Author(s): Ziga Jakopin

Volume 13, Issue 1, 2016

Page: [126 - 131] Pages: 6

DOI: 10.2174/1570179412666150505184852

Price: $65


We present a straightforward route for the preparation of orthogonally protected oxadiazole-based building blocks in high yields. Their structures contain a Boc-protected amine and an ester group, thus rendering the compounds amenable to functionalization or integration into larger structures. Thus, we provided access to interesting and innovative building blocks/decorated scaffolds for drug discovery.

Keywords: 1, 2, 4-oxadiazole, 1, 3, 4-oxadiazole, building block, privileged structure, scaffold.

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