Dual Inhibition and Monitoring of Beta-Amyloid Fibrillation by a Luminescent Iridium(III) Complex

Title:Dual Inhibition and Monitoring of Beta-Amyloid Fibrillation by a Luminescent Iridium(III) Complex

Volume: 12 Issue: 5

Author(s): Chun-Yuen Wong, Lai-Hon Chung, Lihua Lu, Modi Wang, Bingyong He, Li-Juan Liu, Chung-Hang Leung and Dik-Lung Ma

Affiliation:

Keywords: Amyloid, aggregation, Alzheimer's, luminescent probe, iridium.

Abstract: In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.

Cite this article as:

Wong Chun-Yuen, Chung Lai-Hon, Lu Lihua, Wang Modi, He Bingyong, Liu Li-Juan, Leung Chung-Hang and Ma Dik-Lung, Dual Inhibition and Monitoring of Beta-Amyloid Fibrillation by a Luminescent Iridium(III) Complex, Current Alzheimer Research 2015; 12(5) . https://dx.doi.org/10.2174/1567205012666150504144558