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Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

ADP-Ribosyltransferases and Poly ADP-Ribosylation

Author(s): Chao Liu and Xiaochun Yu

Volume 16, Issue 6, 2015

Page: [491 - 501] Pages: 11

DOI: 10.2174/1389203716666150504122435

Price: $65


Protein ADP-ribosylation is an important posttranslational modification that plays versatile roles in multiple biological processes. ADP-ribosylation is catalyzed by a group of enzymes known as ADP-ribosyltransferases (ARTs). Using nicotinamide adenine dinucleotide (NAD+) as the donor, ARTs covalently link single or multiple ADP-ribose moieties from NAD+ to the substrates, forming mono ADP-ribosylation or poly ADP-ribosylation (PARylation). Novel functions of ARTs and ADPribosylation have been revealed over the past few years. Here we summarize the current knowledge on ARTs and PARylation.

Keywords: ADP-ribosylation, ADP-ribosyltransferase, ART, ARTD, PAR, PARylation.

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