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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Chronic Stress Impacts on Olfactory System

Author(s): Ti-Fei Yuan, Gonglin Hou and Oscar Arias-Carrion

Volume 14 , Issue 4 , 2015

Page: [486 - 491] Pages: 6

DOI: 10.2174/1871527314666150429111356

Price: $65


Chronic stress has detrimental effects on brain structures and functions. Previous studies mainly focused on prefrontal cortex and hippocampus, given their well-described roles in cognition and emotive processing. Chronic stress also leads to changes in other neural circuits, such as the olfactory system. Olfactory deficits were reported in both animal models and patients with depression. The present review summarizes the evidence linking chronic stress to neuropathology in the olfactory system, and analyzes the potential mechanistic insights underlying these changes. We propose also that olfactory system-targeting therapies could be beneficial to certain symptoms of patients suffering from stress-related neurological diseases.

Keywords: Chronic stress, limbic system, neurogenesis, olfaction.

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