摘要
已知的细胞内病原体操纵宿主细胞的调控途径,为他们的生长和生存以建立一个最佳的环境。病原菌在宿主细胞代谢中的作用机制,并获得现有的营养和能量储存。在细胞能量平衡调节中细胞能量传感器与活化蛋白激酶的作用(AMPK)是有据可查的。在这里,我们强调了最近的进展表明AMPK在病原与宿主相互作用信号的重要性。病原体通过的一系列旨在重组宿主细胞代谢的自身利益机制AMPK相互作用。AMPK活性刺激提供了一个有效的方法来快速适应往往在感染的不同阶段遇到的病原菌代谢的主要营养变化。然而,抑制AMPK也被用于病原体操纵宿主反应,表明AMPK相关病原体感染的限制。我们也证明药理AMPK调节剂对病原体增殖和存活的影响。本文阐述了复杂的病原体AMPK相互作用可能被利用来抗病原治疗的发展。
关键词: AMPK活化蛋白激酶、细菌、能量代谢、传染病、寄生虫、病原体、药物、疗法、病毒。
Current Drug Targets
Title:AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes?
Volume: 17 Issue: 8
Author(s): Diana Moreira, Ricardo Silvestre, Anabela Cordeiro-da-Silva, Jérôme Estaquier, Marc Foretz, Benoit Viollet
Affiliation:
关键词: AMPK活化蛋白激酶、细菌、能量代谢、传染病、寄生虫、病原体、药物、疗法、病毒。
摘要: Intracellular pathogens are known to manipulate host cell regulatory pathways to establish an optimal environment for their growth and survival. Pathogens employ active mechanisms to hijack host cell metabolism and acquire existing nutrient and energy store. The role of the cellular energy sensor AMP-activated protein kinase (AMPK) in the regulation of cellular energy homeostasis is well documented. Here, we highlight recent advances showing the importance of AMPK signaling in pathogen-host interactions. Pathogens interact with AMPK by a variety of mechanisms aimed at reprogramming host cell metabolism to their own benefit. Stimulation of AMPK activity provides an efficient process to rapidly adapt pathogen metabolism to the major nutritional changes often encountered during the different phases of infection. However, inhibition of AMPK is also used by pathogens to manipulate innate host response, indicating that AMPK appears relevant to restriction of pathogen infection. We also document the effects of pharmacological AMPK modulators on pathogen proliferation and survival. This review illustrates intricate pathogen-AMPK interactions that may be exploited to the development of novel anti-pathogen therapies.
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Cite this article as:
Diana Moreira, Ricardo Silvestre, Anabela Cordeiro-da-Silva, Jérôme Estaquier, Marc Foretz, Benoit Viollet , AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes?, Current Drug Targets 2016; 17 (8) . https://dx.doi.org/10.2174/1389450116666150416120559
DOI https://dx.doi.org/10.2174/1389450116666150416120559 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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