Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

The Role and Predictive Value of Cytokines in Atherosclerosis and Coronary Artery Disease

Author(s): Dimitris Tousoulis, Evangelos K. Economou, Evangelos Oikonomou, Nikolaos Papageorgiou, Gerasimos Siasos, George Latsios, Eleni Kokkou, Kostantinos Mourouzis, Spyridon Papaioannou, Spyridon Deftereos, Michael W. Cleman, Maria Lymberi, Vasiliki Gennimata and Christodoulos Stefanadis

Volume 22 , Issue 22 , 2015

Page: [2636 - 2650] Pages: 15

DOI: 10.2174/0929867322666150415145814

Price: $65

Abstract

Atherosclerosis is currently regarded as a chronic inflammatory disease that is mediated by several types of cells and molecules. Emphasis has been placed on the role of cytokines and the way they act and interact to initiate and sustain inflammation in the microenvironment of an atherosclerotic plaque. Cytokines are invariably expressed by all cells involved in the pathogenesis of atherosclerosis, act on a variety of targets exerting multiple effects and are largely responsible for the crosstalk among endothelial, smooth muscle cells, leukocytes and other vascular residing cells. In the present paper our aim is to review current information on the role of the most commonly discussed cytokines in the process of atherogenesis and to discuss the prognostic significance of these cytokines in atherosclerosis and coronary artery disease.

Keywords: Atherosclerosis, cytokines, coronary artery disease, interleukins, prognostic value.


Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy