摘要
心血管事件如心肌梗死(MI)和由于增强性炎症动脉粥样硬化而患脑卒中增加了类风湿性关节炎(RA)的过早死亡。大量证据表明,加速动脉粥样硬化和RA相关心血管并发症的混淆不仅是通过传统风险因素还有许多免疫和炎症通路。由于慢性炎症和自身免疫性疾病的动脉粥样硬化与RA相关的心血管并发症起到关键作用,有效抑制全身炎症反应可以看作是这种疾病的心血管治疗和预防策略。本文综述了甲氨蝶呤对TRF的作用机制,RA诱导的动脉粥样硬化的临床和亚临床表现,以及相关的心血管疾病的发病率和死亡率。
关键词: 动脉粥样硬化,心血管疾病,炎症,甲氨蝶呤,类风湿性关节炎。
Current Medicinal Chemistry
Title:Cardiovascular Effects of Methotrexate in Rheumatoid Arthritis Revisited
Volume: 22 Issue: 16
Author(s): Tatyana V. Popkova, Diana S. Novikova, Armen Yuri Gasparyan and Evgeny L. Nasonov
Affiliation:
关键词: 动脉粥样硬化,心血管疾病,炎症,甲氨蝶呤,类风湿性关节炎。
摘要: Cardiovascular events such as myocardial infarction (MI) and stroke due to enhanced inflammatory atherosclerosis account for increased premature mortality in rheumatoid arthritis (RA). Accumulated evidence suggests that accelerated atherosclerosis and related cardiovascular comorbidities in RA are confounded not only by traditional risk factors (TRF) but also by a number of immune and inflammatory pathways. Since chronic inflammation and autoimmune disorders play a key role in atherosclerosis and related cardiovascular complications in RA, effective suppression of systemic inflammation can be viewed as a strategy for cardiovascular therapy and prevention in this disease. This article overviews some mechanisms of action of methotrexate on TRF, clinical and subclinical manifestations of RA-induced atherosclerosis, and related cardiovascular morbidity and mortality.
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Tatyana V. Popkova, Diana S. Novikova, Armen Yuri Gasparyan and Evgeny L. Nasonov , Cardiovascular Effects of Methotrexate in Rheumatoid Arthritis Revisited, Current Medicinal Chemistry 2015; 22 (16) . https://dx.doi.org/10.2174/0929867322666150415122039
DOI https://dx.doi.org/10.2174/0929867322666150415122039 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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