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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Outlook for Aptamers After Twenty Five Years

Author(s): Phepafatso K. Tsae and Maria C. DeRosa

Volume 15, Issue 12, 2015

Page: [1153 - 1159] Pages: 7

DOI: 10.2174/1568026615666150413154038

Price: $65


Twenty-five years after the emergence of powerful molecular recognition elements known as aptamers, these synthetic receptors are finding applications in therapeutics, imaging, diagnostics and biosensors. Comparisons have been drawn between aptamers and antibodies since their earliest days. This review will highlight how some of the most promising and successful aptamer-based applications have exploited the advantages aptamers have over their antibody counterparts and will point to future applications of this enabling technology.

Keywords: Antibodies, Aptamers, Biosensors, Imaging, SELEX, Therapeutics.

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