摘要
N-甲基-D-天冬氨酸盐(NMDA)受体在学习记忆中扮演着非常重要的角色。NMDA受体是由两分子甘氨酸亚基捆绑CluN1和两分子谷氨酸捆绑的亚基(例如GluN2A, GluN2B, GluN2C和 GluN2D),及GluN2亚基和甘氨酸捆绑的GluN3亚基(例如GluN3A或者GluN3B),或者两分子GluN3亚基组成的四聚物。最近的研究表明,每个亚基的具体表达和分布都深深影响着神经的兴奋性,可塑性和突触不足。这篇文章总结了关于NMDA受体的功能紊乱和存在于不同的神经和精神疾病(包括精神分裂症,自身免疫引起的谷氨酸能受体紊乱、情绪异常和孤独症)中的相应的亚基的相关报导。最近,一个在NMDA受体拮抗剂诱导的精神病中的GluN2D亚基的主要功能被揭示了。
关键词: GluN1
Current Molecular Medicine
Title:Specific Roles of NMDA Receptor Subunits in Mental Disorders
Volume: 15 Issue: 3
Author(s): H. Yamamoto, Y. Hagino, S. Kasai and K. Ikeda
Affiliation:
关键词: GluN1
摘要: N-methyl-D-aspartate (NMDA) receptor plays important roles in learning and memory. NMDA receptors are a tetramer that consists of two glycine-binding subunits GluN1, two glutamate-binding subunits (i.e., GluN2A, GluN2B, GluN2C, and GluN2D), a combination of a GluN2 subunit and glycine-binding GluN3 subunit (i.e., GluN3A or GluN3B), or two GluN3 subunits. Recent studies revealed that the specific expression and distribution of each subunit are deeply involved in neural excitability, plasticity, and synaptic deficits. The present article summarizes reports on the dysfunction of NMDA receptors and responsible subunits in various neurological and psychiatric disorders, including schizophrenia, autoimmune-induced glutamatergic receptor dysfunction, mood disorders, and autism. A key role for the GluN2D subunit in NMDA receptor antagonist-induced psychosis has been recently revealed.
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Cite this article as:
H. Yamamoto, Y. Hagino, S. Kasai and K. Ikeda , Specific Roles of NMDA Receptor Subunits in Mental Disorders, Current Molecular Medicine 2015; 15 (3) . https://dx.doi.org/10.2174/1566524015666150330142807
DOI https://dx.doi.org/10.2174/1566524015666150330142807 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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