Abstract
A simple and straightforward three-component methodology for the solution phase high-throughput synthesis of 2,5-disubstituted pyridazin-3(2H)-one libraries has been developed. The diversity at position 5 of the heterocycle is determined by the use of Suzuki, Sonogashira, Heck or Stille coupling.
Keywords: Multicomponent reactions, pyridazinones, palladium, combinatorial chemistry
Combinatorial Chemistry & High Throughput Screening
Title: Straightforward Three-Component Palladium-Catalysed Synthesis of Pyridazin-3(2H)-one Libraries
Volume: 9 Issue: 1
Author(s): Alberto Coelho and Eddy Sotelo
Affiliation:
Keywords: Multicomponent reactions, pyridazinones, palladium, combinatorial chemistry
Abstract: A simple and straightforward three-component methodology for the solution phase high-throughput synthesis of 2,5-disubstituted pyridazin-3(2H)-one libraries has been developed. The diversity at position 5 of the heterocycle is determined by the use of Suzuki, Sonogashira, Heck or Stille coupling.
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Cite this article as:
Coelho Alberto and Sotelo Eddy, Straightforward Three-Component Palladium-Catalysed Synthesis of Pyridazin-3(2H)-one Libraries, Combinatorial Chemistry & High Throughput Screening 2006; 9 (1) . https://dx.doi.org/10.2174/138620706775213868
DOI https://dx.doi.org/10.2174/138620706775213868 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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