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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Straightforward Three-Component Palladium-Catalysed Synthesis of Pyridazin-3(2H)-one Libraries

Author(s): Alberto Coelho and Eddy Sotelo

Volume 9, Issue 1, 2006

Page: [15 - 19] Pages: 5

DOI: 10.2174/138620706775213868

Price: $65


A simple and straightforward three-component methodology for the solution phase high-throughput synthesis of 2,5-disubstituted pyridazin-3(2H)-one libraries has been developed. The diversity at position 5 of the heterocycle is determined by the use of Suzuki, Sonogashira, Heck or Stille coupling.

Keywords: Multicomponent reactions, pyridazinones, palladium, combinatorial chemistry

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