Abstract
Inflammation is a protective response to eliminate cytotoxic agents and pathogens. Various factors are thought to be involved in the pathological changes in tissues caused by inflammation. Interleukin 1, an inflammatory cytokine, is thought to have diverse physiological functions and to play an important role in inflammatory disease. In this review, we discuss interleukin-1 as a target of inflammatory disease.
Keywords: Infectious diseases, inflammasome, inflammation, interleukin-1β, receptors, tissue.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:IL-1 as a target in inflammation
Volume: 15 Issue: 3
Author(s): Yuki Ito, Naoe Kaneko, Tomoyuki Iwasaki, Shinnosuke Morikawa, Kentaro Kaneko and Junya Masumoto
Affiliation:
Keywords: Infectious diseases, inflammasome, inflammation, interleukin-1β, receptors, tissue.
Abstract: Inflammation is a protective response to eliminate cytotoxic agents and pathogens. Various factors are thought to be involved in the pathological changes in tissues caused by inflammation. Interleukin 1, an inflammatory cytokine, is thought to have diverse physiological functions and to play an important role in inflammatory disease. In this review, we discuss interleukin-1 as a target of inflammatory disease.
Export Options
About this article
Cite this article as:
Ito Yuki, Kaneko Naoe, Iwasaki Tomoyuki, Morikawa Shinnosuke, Kaneko Kentaro and Masumoto Junya, IL-1 as a target in inflammation, Endocrine, Metabolic & Immune Disorders - Drug Targets 2015; 15 (3) . https://dx.doi.org/10.2174/1871530315666150316123657
DOI https://dx.doi.org/10.2174/1871530315666150316123657 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
Call for Papers in Thematic Issues
Advancing Therapies for Bone and Joint Diseases: Insights from Natural Products and Herbal Medicines
The aging global population is experiencing an increased risk of bone and joint health issues, notably osteoporosis and osteoarthritis, affecting over half of individuals over 60. Plant-based natural products and herbal medicines are gaining recognition as alternative therapies for these conditions, with secondary metabolites, including flavonoids, coumarins, and others, playing ...read more
Association between Diabetes Mellitus and natural product complementary applications: State of the arts
Diabetes Mellitus (DM) represents a significant global health challenge, characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The increasing prevalence of DM, alongside its associated complications, has prompted researchers and healthcare professionals to explore a variety of management strategies beyond conventional pharmacotherapy. Among these ...read more
Chronic inflammation and Disorders/Cancers
Chronic inflammation is fundamental cause of variety of disorders. Many lifestyle-related diseases including metabolic syndrome, obesity, impairment of immune responses, sepsis, mental illness, and other disorders are caused by chronic inflammation. Prevention of chronic inflammation is related to antiaging effects of our body. Proinflammatory cytokines such as TNF-α is associated ...read more
Immune defense of the blood-tissue barriers which are related to drugs, metabolic and hormones
We have already known that testis is an immune privilege area for the maintenance of spermatogenesis against to any pathogen from the interstitial area. With the BTB integrity there is a qualified selection for the mature sperm until the lumen migration which is sperm release progress. Spermiogenesis help for the ...read more

- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pleiotropic Effects of Statins - Clinical Evidence
Current Pharmaceutical Design Use of Paediatric Xylometazoline Nasal Drop is not a Child’s Play in Hypertensive Patients on Bisoprolol: A Case Report
Current Drug Safety Continuous Glucose Monitoring: Is it Helpful in Pregnancy?
Current Diabetes Reviews Biological Mechanisms Linking Alzheimer's Disease and Type-2 Diabetes Mellitus
CNS & Neurological Disorders - Drug Targets Risk Factors for Ischemic Heart Disease
Reviews on Recent Clinical Trials A Prevention of Pre-eclampsia with the Use of Acetylsalicylic Acid and Low-molecular Weight Heparin – Molecular Mechanisms
Current Pharmaceutical Biotechnology T-type Ca Channel Blockers in Patients with Chronic Kidney Disease in Clinical Practice
Current Hypertension Reviews Lithium and Kidney, 60 Years Later
Current Drug Safety Possible Involvement of Angiogenesis in Chronic Liver Diseases: Interaction Among Renin-Angiotensin-Aldosterone System, Insulin Resistance and Oxidative Stress
Current Medicinal Chemistry Interferons: Mechanisms, Biological Activities and Survey of their Use in Human Diseases
Current Bioactive Compounds Insulin Resistance in Type 2 Diabetes - Role of the Adipokines
Current Molecular Medicine The Current and Forecasted Status of Type 2 Diabetes in the Arab Society of Israel
Current Diabetes Reviews Apoptosis and Autoimmune Disease
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents MicroRNAs as Candidate Drug Targets for Cardiovascular Diseases
Current Drug Targets Comparison of Dietary Approaches to Treat Obesity Based on the Different Carbohydrate/Fat Content: Impact on Weight Loss and Lipid Profile
Current Nutrition & Food Science Nesfatin/Nucleobindin-2 (NUCB2) and Glucose Homeostasis
Current Hypertension Reviews Treating Dyslipidemias: Is Inflammation the Missing Link?
Medicinal Chemistry HPTLC Method for the Determination of Metformin Hydrochloride, Saxagliptin Hydrochloride, and Dapagliflozin in Pharmaceuticals
Current Analytical Chemistry Prioritizing Disease Genes by Using Search Engine Algorithm
Current Bioinformatics The Importance of Strict Blood Glucose Control with Insulin Therapy in the Intensive Care Unit
Current Diabetes Reviews