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Current Tissue Engineering (Discontinued)

Editor-in-Chief

ISSN (Print): 2211-5420
ISSN (Online): 2211-5439

Cellular Cardiomyoplasty – Challenges of a New Era

Author(s): Esko Kankuri, Milla Lampinen and Ari Harjula

Volume 4 , Issue 1 , 2015

Page: [41 - 46] Pages: 6

DOI: 10.2174/2211542004666150305235238

Price: $65

Abstract

Cell therapy for the failing heart has advanced in distinct phases or era with a first transition from dynamic to cellular cardiomyoplasty. Currently, the quest is to find the optimal replacement cell type or to engineer a substitute for the dysfunctional scarred tissue. Cell therapies still require major refinements before they can—in a truly therapeutic manner—aid the suffering myocardium that fails either to adequately support contraction or to permit dilatation. Here, we outline the road so far and provide an insight into current and future challenges that await resolving.

Keywords: Autologous cell therapy, cardiomyoplasty, extracellular matrix, heart failure, micrografts, tissue.


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