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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

The Processing of Chitosan and Its Derivatives and Their Application for Postoperative Anti-Adhesion

Author(s): Lin Zhu, Lin Peng and Yu-Qing Zhang

Volume 15, Issue 4, 2015

Page: [330 - 337] Pages: 8

DOI: 10.2174/1389557515666150227110547

Price: $65


The formation of peritoneal adhesions represents one of the most common complications after abdominal surgery, and it increases the difficulty of re-operation. Thus, preventing postoperative adhesions is a major problem in the field of surgical medicine. Due to a lack of good predictive animal models and the complexity of adhesion pathogenesis, attempts to prevent or reduce peritoneal adhesions have been largely unsuccessful. As a result, the study of anti-adhesion drugs and materials has become a hot topic for experts and scholars. The processing and development of chitosan and its derivatives as new anti-adhesion materials is highly valued because chitosan is inexpensive, highly biocompatible, and not cytotoxic, making it a promising anti-adhesion material. Here, we review the sources and preparation of chitosan and the progress made toward producing different types of chitosan and its derivatives for preventing adhesion.

Keywords: Chitosan, carboxymethyl chitosan, postoperative peritoneal anti-adhesion.

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