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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Review Article

Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma

Author(s): Sergio A. Gradilone*, Maria J. Lorenzo Pisarello and Nicholas F. LaRusso

Volume 18 , Issue 8 , 2017

Page: [958 - 963] Pages: 6

DOI: 10.2174/1389450116666150223162737

Price: $65

Abstract

Cilia are microtubule-based organelles, which are ubiquitously expressed in epithelial cells. Cholangiocytes, the epithelial cells lining the biliary tree, have primary cilia extending from their apical plasma membrane into the ductal lumen, where the cilia function as multisensory organelles transducing environmental cues into the cell interior. The decrease or loss of primary cilia has been described in several malignancies, including cholangiocarcinoma, suggesting that the loss of cilia is a common occurrence in neoplastic transformation. In this short review, we describe the expression of cilia in several cancers, explore the mechanisms and consequences of ciliary loss, and discuss the potential use of the primary cilia as therapeutic targets.

Keywords: Primary cilia, cholangiocarcinoma, ciliotherapy, HDAC6, cholangiocyte, bile duct cancer.

Graphical Abstract

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