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Current Cancer Drug Targets


ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Exploiting Novel Cell Cycle Targets in the Development of Anticancer Agents

Author(s): Chung Fai Wong, Alexander Guminski, Nicholas A. Saunders and Andrew J. Burgess

Volume 5, Issue 2, 2005

Page: [85 - 102] Pages: 18

DOI: 10.2174/1568009053202090

Price: $65


In this review we provide a brief background on the cell cycle and then focus on two novel and emerging areas of cell cycle research that may prove to have significant relevance to the development of novel anticancer agents. In particular, we review the emerging evidence to suggest that histone deacetylase inhibitors may possess cancer cell-specific cytotoxicity due to their ability to target a novel G2/M checkpoint. We also review the recent literature supporting the proposition that inhibition of E2F activity in epithelial cancer cells may prove to be a useful differentiation therapy that operates via cell cycle-dependent and cell cycleindependent mechanisms.

Keywords: angiogenesis, dna replication, mitosis, cyclin dependent kinase inhibitors, transcription, phosphorylation

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