Cell Penetrating Peptides as a Therapeutic Strategy in Chronic Lymphocytic Leukemia

Title:Cell Penetrating Peptides as a Therapeutic Strategy in Chronic Lymphocytic Leukemia

Volume: 22 Issue: 6

Author(s): Issam Arrouss, Didier Decaudin, Sylvain Choquet, Nabih Azar, Christophe Parizot, Jean M. Zini, Fariba Nemati and Angelita Rebollo

Affiliation:

Keywords: apoptosis, Caspase-9, CLL, penetrating peptides, PP2A.

Abstract: PP2A is a serine/threonine phosphatase critical to a number of physiological and developmental processes. In this manuscript, we show that a peptide, specifically blocking the caspase- 9/PP2A interaction, DPT-C9h, induces apoptosis in primary tumour B cells isolated from peripheral blood mononuclear cells or bone marrow of chronic lymphocytic leukemia (CLL) patients, but not on B cells obtained from healthy donors (HD). Moreover, in both CLL patients and HD, DPT-C9h does not induce apoptosis on T- and NKcells and monocytes. Our results strongly suggest that DPT-C9h peptide has tumour specificity and that caspase-9/PP2Ac interaction constitutes a novel therapeutic approach for the treatment in CLL patients.

Cite this article as:

Arrouss Issam, Decaudin Didier, Choquet Sylvain, Azar Nabih, Parizot Christophe, Zini M. Jean, Nemati Fariba and Rebollo Angelita, Cell Penetrating Peptides as a Therapeutic Strategy in Chronic Lymphocytic Leukemia, Protein & Peptide Letters 2015; 22 (6) . https://dx.doi.org/10.2174/0929866522666150216115352