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Current Microwave Chemistry


ISSN (Print): 2213-3356
ISSN (Online): 2213-3364

A Rapid Protocol to Synthesize γ-Butyrolactone Derivatives via the Microwave Technique

Author(s): Marcos F. Pinatto-Botelho and Paulo Marcos Donate

Volume 2, Issue 1, 2015

Page: [83 - 87] Pages: 5

DOI: 10.2174/221333560201150212113120

Price: $65


This work reports the synthesis of several 3-methoxycarbonyl-γ-butyrolactone derivatives (4-12) starting from dimethyl itaconate (1), an aryl bromide (2), and a carbonyl compound (3). The synthetic protocol used microwave irradiation, argon atmosphere, and acetonitrile as solvent. The synthesis furnished the target compounds in 80-96% yield; reactions lasted about 10-20 min.

Keywords: γ-butyrolactone, 3-methoxycarbonyl-γ-butyrolactone, aryl bromide, biologically active compounds, carbonyl compounds, dimethyl itaconate, ESI MS data, MCR, microwave irradiation, microwave-assisted synthesis, multicomponent reaction, NMR data, one pot reaction, organic synthesis.

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