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Current Microwave Chemistry


ISSN (Print): 2213-3356
ISSN (Online): 2213-3364

Solvent and Catalyst Free, Regioselective α-Bromination of Aralkyl Ketones Using N-Bromosuccinimide (NBS) Under Microwave Irradiation: An Efficient Protocol

Author(s): Rajesh H. Vekariya, Shyamali N. Panchal, Kinjal D. Patel and Hitesh D. Patel

Volume 2, Issue 1, 2015

Page: [61 - 68] Pages: 8

DOI: 10.2174/221333560201150212111506

Price: $65


An exceptionally efficient, environmentally safe and economic method has been developed for regioselective α-bromination of various aralkyl ketones in excellent yield with N-bromosuccinimide (NBS) under microwave irradiation (CEM discover) without use of either a solvent or a catalyst. After completion of the reaction, the NBS can be regenerated by using an environment friendly brominating agent NaBr/NaBrO3 in acetic acid. The present procedure offers various advantages such as a very short reaction time, simple work-up procedure, excellent yield of products and recovery of the reagents by green protocol.

Keywords: α-bromination, catalyst free, efficient protocol green bromination, microwave irradiation, N-bromosuccinimide, regeneration, regioselectivity, solvent free.

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