Abstract
An exceptionally efficient, environmentally safe and economic method has been developed for regioselective α-bromination of various aralkyl ketones in excellent yield with N-bromosuccinimide (NBS) under microwave irradiation (CEM discover) without use of either a solvent or a catalyst. After completion of the reaction, the NBS can be regenerated by using an environment friendly brominating agent NaBr/NaBrO3 in acetic acid. The present procedure offers various advantages such as a very short reaction time, simple work-up procedure, excellent yield of products and recovery of the reagents by green protocol.
Keywords: α-bromination, catalyst free, efficient protocol green bromination, microwave irradiation, N-bromosuccinimide, regeneration, regioselectivity, solvent free.
Current Microwave Chemistry
Title:Solvent and Catalyst Free, Regioselective α-Bromination of Aralkyl Ketones Using N-Bromosuccinimide (NBS) Under Microwave Irradiation: An Efficient Protocol
Volume: 2 Issue: 1
Author(s): Rajesh H. Vekariya, Shyamali N. Panchal, Kinjal D. Patel and Hitesh D. Patel
Affiliation:
Keywords: α-bromination, catalyst free, efficient protocol green bromination, microwave irradiation, N-bromosuccinimide, regeneration, regioselectivity, solvent free.
Abstract: An exceptionally efficient, environmentally safe and economic method has been developed for regioselective α-bromination of various aralkyl ketones in excellent yield with N-bromosuccinimide (NBS) under microwave irradiation (CEM discover) without use of either a solvent or a catalyst. After completion of the reaction, the NBS can be regenerated by using an environment friendly brominating agent NaBr/NaBrO3 in acetic acid. The present procedure offers various advantages such as a very short reaction time, simple work-up procedure, excellent yield of products and recovery of the reagents by green protocol.
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Cite this article as:
Vekariya H. Rajesh, Panchal N. Shyamali, Patel D. Kinjal and Patel D. Hitesh, Solvent and Catalyst Free, Regioselective α-Bromination of Aralkyl Ketones Using N-Bromosuccinimide (NBS) Under Microwave Irradiation: An Efficient Protocol, Current Microwave Chemistry 2015; 2 (1) . https://dx.doi.org/10.2174/221333560201150212111506
DOI https://dx.doi.org/10.2174/221333560201150212111506 |
Print ISSN 2213-3356 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3364 |
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Advances in Drug Delivery Carriers Used in Microwave-Assisted Reactions for Enhanced Therapeutics and Diagnostic Purposes
Microwave irradiation technology has numerous applications in organic synthesis, pharmaceuticals, and the development of nanocarriers. To date, microwave-assisted reactions have garnered significant attention in synthesizing drug delivery carriers. Considering the advantages of microwave-assisted reactions, such as high percentage yield, shorter reaction time, and compound purity, microwave-assisted technology holds promise in ...read more
Advances in Microwave-Assisted Synthesis: Innovations and Applications
Microwave-assisted synthesis has emerged as a pivotal technique in modern chemistry, offering enhanced reaction rates, improved yields, and reduced energy consumption. This thematic issue aims to capture the latest innovations in microwave-assisted synthesis, highlighting its transformative impact on various chemical disciplines, including organic synthesis, materials science, pharmaceuticals, and environmental chemistry. ...read more
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