Synthesis of (S)-(+)-2-(N-benzylamino)butan-1-ol from its Schiff Base by Catalytic Hydrogenation over Palladium

Title:Synthesis of (S)-(+)-2-(N-benzylamino)butan-1-ol from its Schiff Base by Catalytic Hydrogenation over Palladium

Volume: 2 Issue: 3

Author(s): Laszlo Hegedus, Sandor Miskolczi, Gyorgy Bansaghi, Edit Szekely and Ferenc Faigl

Affiliation:

Keywords: Heterogeneous catalysis, hydrogenation, palladium, supported metal catalyst.

Abstract: A chiral 1,2-amino alcohol derivative, (S)-(+)-2-(N-benzylamino)butan-1-ol (BAB), was synthesized from its Schiff base by catalytic hydrogenation over palladium on carbon, in various solvents (toluene, methanol, hexane, dichloromethane, tetrahydrofuran, ethyl acetate), under mild conditions (room temperature, atmospheric pressure). Preparation of the Schiff base was also optimized. This compound is a resolving agent for preparing optically active, practically important cyclopropanecarboxylic acids.

Cite this article as:

Hegedus Laszlo, Miskolczi Sandor, Bansaghi Gyorgy, Szekely Edit and Faigl Ferenc, Synthesis of (S)-(+)-2-(N-benzylamino)butan-1-ol from its Schiff Base by Catalytic Hydrogenation over Palladium, Current Green Chemistry 2015; 2 (3) . https://dx.doi.org/10.2174/2213346102666150211001310