Abstract
Dormancy in mycobacteria is defined as a stable but reversible non-replicating state in response to stresses. In Mycobacterium tuberculosis, an important human pathogen, this state is responsible for latent Tuberculosis. The current chemotherapy to defeat Tuberculosis while effective in killing growing tubercle bacilli is largely ineffective in killing dormant bacilli. For this reason there is a recent interest to develop new drugs against this disease in the latent form. To this aim, the knowledge of the molecular basis of bacterial resuscitation from dormancy is necessary and of paramount importance. This review summarizes the current knowledge on the complex mechanism of exit from mycobacterial dormancy; the main molecular players responsible for mycobacterial resuscitation from dormancy are described and their role is discussed from a structural perspective.
Keywords: Dormancy, mycobacteria, resuscitation, structure.
Current Medicinal Chemistry
Title:Exit from Mycobacterial Dormancy: A Structural Perspective
Volume: 22 Issue: 14
Author(s): Flavia Squeglia, Alessia Ruggiero and Rita Berisio
Affiliation:
Keywords: Dormancy, mycobacteria, resuscitation, structure.
Abstract: Dormancy in mycobacteria is defined as a stable but reversible non-replicating state in response to stresses. In Mycobacterium tuberculosis, an important human pathogen, this state is responsible for latent Tuberculosis. The current chemotherapy to defeat Tuberculosis while effective in killing growing tubercle bacilli is largely ineffective in killing dormant bacilli. For this reason there is a recent interest to develop new drugs against this disease in the latent form. To this aim, the knowledge of the molecular basis of bacterial resuscitation from dormancy is necessary and of paramount importance. This review summarizes the current knowledge on the complex mechanism of exit from mycobacterial dormancy; the main molecular players responsible for mycobacterial resuscitation from dormancy are described and their role is discussed from a structural perspective.
Export Options
About this article
Cite this article as:
Squeglia Flavia, Ruggiero Alessia and Berisio Rita, Exit from Mycobacterial Dormancy: A Structural Perspective, Current Medicinal Chemistry 2015; 22 (14) . https://dx.doi.org/10.2174/0929867322666150209153027
DOI https://dx.doi.org/10.2174/0929867322666150209153027 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Update on the Rheumatologic Manifestations of Malignancy
Current Cancer Therapy Reviews Recent Advances of Fluorescent Technologies for Drug Discovery and Development
Current Pharmaceutical Design Polymorphic Receptors of the Innate Immune System (MBL/MASP-2 and TLR2/4) and Susceptibility to Pneumococcal Bacteremia in HIV-Infected Patients: A Case-Control Study
Current HIV Research Single Amino Acid Repeats Connect Viruses to Neurodegeneration
Current Drug Discovery Technologies Emerging Role of Antioxidants in the Protection of Uveitis Complications
Current Medicinal Chemistry Comprehensive Review and Comparison of Anticancer Peptides Identification Models
Current Protein & Peptide Science Current Strategies in TB Immunotherapy
Current Molecular Medicine Isoniazid Induced Metabolic Acidosis and Renal Dysfunction in an Elderly Patient with Chronic Renal Disease
Current Drug Safety Comparison of HCV Core and CoreE1E2 Virus-Like Particles Generated by Stably Transfected Leishmania tarentolae for the Stimulation of Th1 Immune Responses in Mice
Current Drug Delivery Is There a Role for Antioxidants in the Prevention of Infection-Associated Carcinogenesis and in the Treatment of Infection-Driven Tumors?
Current Topics in Medicinal Chemistry Synthesis of 2-Hydroxynaphthyl Pyrazolines Containing Isoniazid Moiety: A Potential Antitubercular Agent
Letters in Organic Chemistry Novel Benzylidenehydrazide-1,2,3-Triazole Conjugates as Antitubercular Agents: Synthesis and Molecular Docking
Mini-Reviews in Medicinal Chemistry Vesicular Carriers for Skin Drug Delivery: The Pheroid™ Technology
Current Pharmaceutical Design Study of Stability of New Mutual Prodrugs with Antimycobacterial Activity
Current Organic Chemistry Nutrition in Infancy
Current Pediatric Reviews Graphical Abstracts
Letters in Drug Design & Discovery Women’s Health in Central America: The Complexity of Issues and the Need to Focus on Indigenous Healthcare
Current Women`s Health Reviews The Immunopathology of Tuberculosis – An Update
Current Respiratory Medicine Reviews The Yin and Yang of Inflammation
Current Molecular Medicine Editorial [Hot topic: QSAR and Complex Networks in Pharmaceutical Design, Microbiology, Parasitology, Toxicology, Cancer and Neurosciences (Executive Editor: Humberto Gonzalez-Diaz)]
Current Pharmaceutical Design