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Current Vascular Pharmacology


ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

Microcirculation in Hypertension: An Update on Clinical Significance and Therapy

Author(s): Costas Tsioufis, Kyriakos Dimitriadis, Niki Katsiki and Dimitris Tousoulis

Volume 13 , Issue 3 , 2015

Page: [413 - 417] Pages: 5

DOI: 10.2174/1570161113666150206110512

Price: $65


Essential hypertension is closely related to alterations of the microcirculation as evidenced by increased media-to-lumen ratio of small resistance arteries and capillary rarefaction. It has been proposed that microvasculature alterations can further deteriorate target organ damage under the influence of increased hemodynamic load in hypertension. More than a decade ago, small artery structure was found to be the most potent predictor of cardiovascular events in essential or secondary hypertension. Amelioration of resistance vessel structure by antihypertensive drugs showed a clear benefit when patients were treated with calcium antagonists and renin-angiotensin-aldosterone inhibitor regimens. Well-designed controlled studies are needed to address the important questions whether different antihypertensive agent combinations could be related to diverse microcirculatory “responses” in terms of structure and function.

Keywords: Hypertension, microcirculation, small arteries resistance, cardiovascular events, antihypertensive drugs.

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