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Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Antioxidant Potentials and Xanthine Oxidase Inhibitory Effect of Two Furanocoumarins Isolated from Tamus communis L

Author(s): Fatima Zerargui, Sabah Boumerfeg, Noureddine Charef, Abderrahmane Baghiani, Meriem Djarmouni, Seddik Khennouf, Lekhmici Arrar, Musa H. Abu Zarga and Mohammad S. Mubarak

Volume 11 , Issue 5 , 2015

Page: [506 - 513] Pages: 8

DOI: 10.2174/1573406411666150130145246

Price: $65

Abstract

In this investigation, the screening of two furanocoumarins; 5,8- dimethoxypsoralen (1) and heraclinin (2), isolated from the methanol root-extracts of Tamus communis L for their antioxidant activity and xanthine oxidase inhibitory effect was carried out, using different assays such as DPPH free radical scavenging effect, - carotene / linoleic acid, xanthine oxidase (XO) inhibition and in addition to blood total antioxidant capacity. Results revealed that the two compounds have significant DPPH radical scavenging activity and effective inhibition of linoleic acid oxidation in a dose-dependent manner; 5,8-dimethoxypsoralen exhibited the highest activity with an I% = 72.69 ± 1.88 %. These results indicate that the isolated compounds inhibit xanthine oxidase activity and scavenge superoxide radicals with heraclinin (2) as the more potent xanthine oxidase inhibitor, and 5,8-dimethoxypsoralen (1) as the more effective on cytochrome c reduction, the two tested compounds can effectively protect erythrocytes against hemolytic injury induced by AAPH. These results are promising for further studies of the biological and pathological effects of these natural products.

Keywords: Antioxidant activity, furanocoumarins, polyphenols, scavenging, Tamus communis L., xanthine oxidase, hemolysis.

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