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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance

Author(s): Shuaizhang Li, Wen Zhang, Xuejiao Yin, Shilai Xing, Heidi Qunhui Xie, Zhengyu Cao and Bin Zhao

Volume 15, Issue 4, 2015

Page: [423 - 432] Pages: 10

DOI: 10.2174/1871520615666150129212723

Price: $65


The ABC (ATP-binding cassette) transporter is one of the largest and most ancient protein families with members functioning from protozoa to human. The resistance of cancer and tumor cells to anticancer drugs is due to the over-expression of some ABC transporters, which may finally lead to chemotherapy failure. The mouse ABC transporters are classified into seven subfamilies by phylogenetic analysis. The mouse ABC transporter gene, alias, chromosomal location and function have been determined. Within the ABC super-family, the MDR transporters (Abcb1, Abcc1, Abcg2) in mouse models have been proved to be valuable to investigate the biochemistry and physiological functions. This review concentrates on the multidrug resistance of mouse ABC transporters in cancer and tumor cells.

Keywords: ATP-binding cassette (ABC) transporter, cancer, inhibitors, multi-drug resistance, substrate.

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